Production of polyhydroxyalkanoates and their medical applications Roy, I. Varna, Bulgaria 18 Sep Briefly, good control of calcium phosphate crystallization was achieved with films containing negatively charged lipid and higher excess of the lipid for anionic and zwitterionic lipids. The homopolymer poly 3-hydroxyoctanoate as a matrix material for soft tissue engineering Rai, R. References Akiyama M, Tsuge T, Doi Y Environmental life cycle comparison of polyhydroxyalkano- ates produced from renewable carbon resources by bacterial fermentation. Journal of Applied Polymer Science. Production of polyhydroxyalkanoates and their biomedical applications Roy, I.
Polyhydroxyoctanoate P 3HO , a medium chain length polyhydroxyalkanoate homopolymer from Pseudomonas mendocina. Since any foreign material introduced to the body is recognized by its surface, tissue engineering research turns towards controlled assembly of inorganic components at the nanoscale, directed by molecularly organized polymer scaffolds, by a so-called bottom-up approach. Interactions of the polymer with biologically important molecules, cell membrane lipids, in mixed Langmuir films were evaluated — this approach is a simple method to model the behavior of living cells in the presence of a synthetic implant material. Journal of Applied Microbiology. A handbook of applied biopolymer technology: Polym Degrad Stab Proceedings of Euromat , Glasgow, 7 – 10 September Euromat.
The study of PHA interactions with lipids provides additional insights for development of e.
Theesis elastomeric poly 3-hydroxyoctanoate based natural polymer composite for enhanced keratinocyte regeneration. Proceedings of EuromatGlasgow, 7 – 10 September Euromat. Appl Environ Microbiol Production of polyhydroxyalkanoates and their medical applications.
Polyhydroxyalkanoates are polyesters of 3-hydroxyalkanoic acids produced by numerous Gram positive and Gram negative bacteria under nutrient limiting conditions. This is the first time that an absolute homopolymer fhesis P 3HO poljhydroxyalkanoates been produced. Furthermore, the results may be also of interest for applications where properties of thin, molecularly organized films are crucial for the product design and performance, such as sensors.
Varna, Bulgaria 18 Sep The interactions were highly reliant on the lipid head group size and orientation at the free water surface, and are interpreted considering intra- and intermolecular forces between lipid and polymer molecules.
Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future Rai, R. In the broader context, the outcome of this work may have impact not only on PHA-based materials, but also on the understanding of other polyester-based biomaterials.
Highly elastomeric poly 3-hydroxyoctanoate based natural polymer composite for enhanced keratinocyte regeneration Rai, R. The homopolymer poly 3-hydroxyoctanoate as a matrix material for soft tissue engineering. Polym Degrad Stab Production of Polyhydroxyalkanoates from Polhyydroxyalkanoates cereus SPV under different nutrient limiting conditions.
Industrial production of PHA
Biodegradable polymers and green chemistry Royal Society of Chemistry. Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future. Antonie Van Leewenhoek This has been pointed out in Chapter 5: The homopolymer poly 3-hydroxyoctanoate as a matrix material for soft tissue polyhydroxyalkanoatea Rai, R.
Polyhydroxyalkanoates, the emerging new green polymers of choice Rai, R. Milan, Italy 2nd – 4th March In vitro degradation studies revealed the films both neat and composite underwent hydrolytic degradation which started at the surface and that aged with time.
Microbial PHA biosynthesis and its applications. The main aim of this study was to investigate PHA production in microorganisms and utilise the PHA produced for medical polyhydroxyalkahoates.
Biosynthesis of polyhydroxyalkanoates and its medical applications : WestminsterResearch
For high-value-added applications, PHA can be exploited as bioimplant materials, tissue engineering materials Chen and Wu aand smart materials Monomers and oligomers of PHA can be used as nutri- tional and energy supplements for animals or even humans, and they can also be used as drugs or fine chemicals Yao et al. Imaging internal features of whole, unfixed bacteria Thomson, N. Both the neat and composite films were able to support the attachment, growth and proliferation of the HaCaT cells.
Abstract Novel polymer-inorganic composites attract scientific and commercial attention as potential biomaterials for orthopedic applications, due to the fact that currently used materials have still many drawbacks, e.
Interactions of the polymer with biologically important molecules, cell membrane lipids, in mixed Langmuir films were evaluated — this approach is a simple method to model the behavior of living cells in the presence of a synthetic implant material.
Last, but not least, calcium phosphate crystallization beneath PHAs and its mixed films with lipids may inspire new developments in bone tissue engineering using naturally synthesized polymers. Polyhydfoxyalkanoates was suitable for its use as a pericardial patch material.
Biotechnical Functionalisation of Renewable Polymeric Materials: The polymer was fabricated into neat P 3HO films to be used a biomaterial for pericardial patch application. An optimised extraction method using a dispersion of hypochlorite and chloroform combined with an optimised polymer purification was found to extract P 3HO efficiently and also reduce the amount of LPS to an FDA approved level polyhydroxyalkankates 0.
For the blend films the surface properties was greatly affected by the amount of P 3HB incorporated.