The study was conducted from December to October Further testing was performed at min intervals until the recovery of S2 dermatome. With the patient in sitting position, lumbar puncture was performed at L intervertebral space with 25 G pencil point Quinke spinal needle with all aseptic precautions. According to Gertler R et al. But one has to be vigilant because a good number of patients had a fall in heart rate and BP when 15 and 20 mcg dose of dexmedetomidine were used intrathecally. Block regression was significantly slower with the addition of intrathecal dexmedetomidine as compared with fentanyl, as both time to two segment regressions and time to S2 regression were significantly more with intrathecal dexmedetomidine.

Monitored anaesthesia care with dexmedetomidine: Am J Appl Sci. We also cannot comment about its effect on patients in extremes of age. This could be due to sedation. The initial hypertensive phase is due to alpha 2B adrenergic receptors whereas hypotension is mediated by the alpha 2A adrenergic receptors.

J Anaesthesiol Clin Pharmacol. Dexmedetomidine is more selective alpha 2 adrenoceptor agonist and has recently been used as adjuvant to intrathecal local anaesthesia [ 4 — 6 ] Previous animal [ 78 ] and human trials [ 5 ] suggest a 1: In our study there were significant increase in the duration of sensory and motor block of spinal anaesthesia and prolonged postoperative analgesia.

This article has been cited by other articles in PMC. Am J Appl Sci. Hala EA Eid et al. So, use of recommended dose of dexmeditimodine in comorbid, elderly and complicated systemic illness should be weighed before use.


A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine

Results were expressed as mean and standard deviation SD or number or intratjecal. Spinal antinociception by dexmedetomidine, a highly selective alpha2-adrenergic agonist. Table 2 Characteristics of sensory block. But in D4 though the incidence of hypotension was high as compared to other groups, nausea and vomitting was not seen in any patient. The study was conducted from December to October Effect of dexmedetomidine added to spinal bupivacaine for urological procedure.

This article has been cited by other articles in PMC. There was no difference between groups D and F in the highest level of block achieved in the two groups T5 and T6, respectively or in the time to reach peak level.

thesis on intrathecal dexmedetomidine

In the operating room ECG, pulse oximetry and non invasive blood pressure were monitored and baseline values were recorded. Journal of Anaesthesiology and Clinical Pharmacology. Onttonen T, Pertovaara A. Six patients in group C and 3 in group D1 also required tramadol. Hence, if we require regional anaesthesia for longer duration we use some additive.

Comparative study of intrathecal dexmedetomidine with intrathecal magnesium sulphate used as adjuvant to bupivacaine. A common problem during lower abdominal surgeries under spinal anesthesia is visceral pain, nausea, and vomiting. The incidence of adverse effects such as nausea, vomiting, shivering, respiratory depression, sedation and hypotension were recorded.


thesis on intrathecal dexmedetomidine

intraathecal A comparison of the hydrochloride salts of lignocaine and prilocaine for epidural analgesia. We also cannot comment about its effect on patients in extremes of age. Drugs were injected within seconds.

A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine

Many animal studies conducted using intrathecal dexmedetomidine at a dose range of 2. Lawrence Erlbaum Associates; Dexmedetomidine is one among them. Similar result was seen by Hala EA Eid et al. A hypnotic thezis to dexmedetomidine, an alphe 2 agonist, is mediated in locus ceruleus in rats. The effects of dexmedetomidine and halothane on the Fos expression in the spinal dorsal horn using a rat postoperative pain model.

Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult

Materials and Methods After getting approval from the Research Ethics and informed consent from adult patients, a randomised controlled, double blinded trial was started. Highest level of sensory blockade, the time to reach this level after injection, dexmedeto,idine time to S1 regression, time to urinate and side effect if any were recorded. Clonidine as an adjuvant to intrathecal local anesthetics for surgery: