CURRICULUM VITAE SFEIR

The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates. Opens in a new tab. Areas of Research Interest and Expertise:

Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. A second area of their interest is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

Hesam Rahmanian Curriculum Vitae – Selections Arts

Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity. Journal sveir Cell Science. Areas of Research Interest and Expertise: Agnel Sfeir is mainly interested in understanding the basic mechanism that leads to telomere length resetting.

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curriculum vitae sfeir

Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence.

Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. Associate Professor, Department of Cell Biology.

curriculum vitae sfeir

Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Our lab is sfeirr interested in understanding the basic mechanism that leads to telomere length resetting. Stop pulling my strings – what telomeres taught us about the DNA damage response.

The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks.

Victor Petrus Sfeir

In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length.

Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Skip to Main Content.

To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. A second area of their interest is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

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Telomeres at a glance. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates.

The former stems from the inherent inability of the replication machinery to fully duplicate linear templates.

Is this your profile? PhD from Southwestern University.

Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination.

See All Publications A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Opens in a new tab.

Rana Salam Curriculum Vitae – Selections Arts

Stressed telomeres without POT1 enhance tumorigenesis [Editorial]. To surmount both problems, cells use telomeres, the sgeir nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

The linearity of chromosomes creates two major problems for eukaryotic cells: The linearity of chromosomes creates two major problems for eukaryotic cells: