While his family gathered to mourn their loss, his brother and sister became ill and later died. In September of , Mary Kellerman gave her year-old daughter a Tylenol when she awoke during the night complaining of a sore throat. An expanded version of the teaching notes and the answer key may be found at the National Center for Case Study Teaching in Science at http: Are there any similarities or connections between these seven individuals? Inside of mitochondria, there are several layers of membranes.
If poison is suspected in the deaths, how would you proceed with the investigation? Subcellular metabolite analysis Detailed analysis of the damaged cells showed that ATP levels in the mitochondria were very low. Hypoxia means that the person suffered from a lack of oxygen, or they were suffocated. Students are asked to read through Part I and then spend minutes in small groups discussing whether they believe these cases are linked. In order to determine which component of cellular respiration is affected, students must understand where these metabolites are used or produced and what their functions are. The symptoms Imagine that you work at the medical examiner’s office for a major metropolitan city.
While his family gathered to mourn their loss, his brother and sister became ill and later died.
Case teachers interested in this case may also be interested in another case in the collection entitled “A Headache to Die For” by Wayne Shew available at http: Since the Chicago Tylenol murders, drug companies have drastically changed how medicines are packaged. Could this loss of function lead to the death of these individuals? Both had taken Tylenol to help them cope with their loss shortly before collapsing; neither survived.
Have you ever thought about why oxygen is so important? At 7 am the next morning, her daughter was found collapsed on the bathroom floor, and later pronounced dead.
The whole chain grinds to a halt and no ATP can be made.
Chicago Cyanide Murders by Tiagin Mijin on Prezi
Nucleophilic reactions between carbonyl compounds and. What additional information would you need to determine if they are connected? The reason for the hypoxia is not always clear at the first examination.
Part I introduces the case and gets students to think epidemiologically about the information they receive. For complaints, use another form. The electron stops at the end of the chain and cannot be passed to oxygen.
Part 2: Chicago Cyanide Murders- A Case Study in Cellular Respiration
While there were many suspects, no one was ever charged with the crime and it is still an ongoing investigation. Science and technology in the Soviet Union. Inside of mitochondria, there are several layers of membranes.
You can add this document to your saved list Sign in Available only to authorized users. An ambulance rushed the girl to a nearby hospital, where she was pronounced dead.
Cyanide acts very quickly, often killing within minutes of ingestion and authorities were slow to identify the cause of the deaths.
While poison is the main suspect in the case, what are other ways a person could die of hypoxia? Adam Janus, a postal worker in another Chicago suburb also died unexpectedly, though originally it was thought he had suffered from a heart attack. Even though the victims died of hypoxia, their level of oxygen in snswers blood was approximately mm Hg.
It presents information about cjanide patients’ levels of different metabolites important during cellular respiration. On further investigation, it was shown that the tissues had major mitochondrial damage. They suspected that someone had tampered with the medication. At 7 am the next morning, her daughter was found collapsed on the bathroom floor, and later pronounced dead.
Chicago Cyanide Murders: A Case Study in Cellular Respiration
The symptoms 15 minutes Part I asks students to play the role of medical examiner and to determine the cause of death of four victims. Develop a hypothesis about which pathway may be affected on the basis of these abnormalities. Given what you know about cyanide poisoning, do you think that giving a person oxygen would be an effective treatment?
What affect would cyanide have on the electron transport chain and the production of ATP? Autopsy report 15 minutes After class discussion of Part I, the instructor reports to the students that indeed all these cases do appear to be connected. Recall that the mitochondrion is sometimes called the “powerhouse” of the cell.
Oxygen then binds with proteins to create water.
After realizing that the electron transport chain was no longer functioning, you started to suspect poisoning and ran a blood test for various poisons that you knew affected the electron transport anseers.
For each metabolite listed in Table 1, describe its role in cellular respiration. Cyanide irreversibly binds to cytochrome c oxidase CcOX of the electron transport chain and prevents the transfer of electrons to oxygen, the final electron acceptor.